SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane

Stable Identifier
R-HSA-8932980
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Serine incorporators 1-5 (SERINC1-5) are membrane-associated proteins that incorporate the polar amino acid serine (L-Ser) into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipids. SERINC3 and 5 have recently been identified to be restrictors to HIV replication in human cells (Fackler 2015, Usami et al. 2015).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-serine transmembrane transporter activity of SERINC3,5,(1,2,4) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created