LYPLA2 hydrolyses PALM-C3,4-GAP43

Stable Identifier
R-HSA-8933328
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Neuromodulin (GAP43) is a protein associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons (Gauthier-Campbell et al. 2004). An acylation/deacylation cycle is necessary to maintain the steady-state subcellular distribution and biological activity of S-acylated proteins and GAP43 is dually palmitoylated at cysteines 3 and 4 (PALM-C3,4-GAP43). Acyl-protein thioesterase 2 (LYPLA2, APT2) is the protein thioesterase involved in the acylation/deacylation cycle for GAP43 (Tomatis et al. 2010).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
palmitoyl-(protein) hydrolase activity of LYPLA2 [cytosol]
Physical Entity
Activity
Orthologous Events