LYPLA2 hydrolyses PALM-C3,4-GAP43

Stable Identifier
R-HSA-8933328
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Neuromodulin (GAP43) is a protein associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons (Gauthier-Campbell et al. 2004). An acylation/deacylation cycle is necessary to maintain the steady-state subcellular distribution and biological activity of S-acylated proteins and GAP43 is dually palmitoylated at cysteines 3 and 4 (PALM-C3,4-GAP43). Acyl-protein thioesterase 2 (LYPLA2, APT2) is the protein thioesterase involved in the acylation/deacylation cycle for GAP43 (Tomatis et al. 2010).

Literature References
PubMed ID Title Journal Year
14978216 Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs

Gauthier-Campbell, C, Bredt, DS, Murphy, TH, El-Husseini, Ael-D

Mol. Biol. Cell 2004
21152083 Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43

Tomatis, VM, Trenchi, A, Gomez, GA, Daniotti, JL

PLoS ONE 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
palmitoyl-(protein) hydrolase activity of LYPLA2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed