MCAT transfers Mal from Mal-CoA to NDUFAB1

Stable Identifier
R-HSA-8933547
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial matrix
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MCAT transfers Mal from Mal-CoA to NDUFAB1
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The ACP (acyl carrier protein) NDUFAB1 is the cofactor protein that covalently binds all fatty acyl intermediates via a phosphopantetheine linkage during the synthesis of fatty acids. Mitochondrial malonyl-CoA-acyl carrier protein transacylase (MCAT, MT) catalyses the transfer of a malonyl moiety from malonyl-CoA (Mal-CoA) to the free thiol group of the phosphopantetheine arm of NDUFAB1, suggesting a possible role in fatty acid biosynthesis in the mitochondrion (Zhang et al. 2003).

Literature References
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
[acyl-carrier-protein] S-malonyltransferase activity of MCAT [mitochondrial matrix]
Physical Entity
MCAT [mitochondrial matrix]
Activity
[acyl-carrier-protein] S-malonyltransferase activity (0004314)
Orthologous Events
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Bos taurus)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Canis familiaris)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Dictyostelium discoideum)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Drosophila melanogaster)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Gallus gallus)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Mus musculus)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Rattus norvegicus)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Sus scrofa)
MCAT transfers Mal from Mal-CoA to NDUFAB1 (Xenopus tropicalis)
Authored
Jassal, B  (2016-08-05)
Reviewed
D'Eustachio, P  (2016-08-12)
Created
Jassal, B  (2016-08-05)