LIFR gene expression

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R-HSA-8934690
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Reaction [omitted]
Species
Homo sapiens
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Binding of the RUNX1:CBFB complex to the promoter of the LIFR gene stimulates LIFR transcription. In contrast, the oncogenic fusion protein RUNX1-ETO, the product of t(8;21) translocation in acute myeloid leukemia (AML), represses transcription of the LIFR gene (Qadi et al. 2016). LIFR encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 (IL6) cytokine family. Signaling by LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola and Babon 2015).

Literature References
PubMed ID Title Journal Year
26060100 The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1

Qadi, AA, Taberlay, PC, Phillips, JL, Young, A, West, AC, Brettingham-Moore, KH, Dickinson, JL, Holloway, AF

J. Cell. Biochem. 2016
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