Binding of the RUNX1:CBFB complex to the promoter of the LIFR gene stimulates LIFR transcription. In contrast, the oncogenic fusion protein RUNX1-ETO, the product of t(8;21) translocation in acute myeloid leukemia (AML), represses transcription of the LIFR gene (Qadi et al. 2016). LIFR encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 (IL6) cytokine family. Signaling by LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola and Babon 2015).