RUNX1 binds PRMT1

Stable Identifier
R-HSA-8934742
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RUNX1 forms a complex with protein arginine methyltransferase 1 (PRMT1) in a RNA- and DNA-independent manner. The interaction with PRMT1 involves the C-terminus of RUNX1. Since PRMT1 colocalizes with RUNX1 at RUNX1 target promoters, RUNX1 is shown as part of the RUNX1:CBFB complex (Zhao et al. 2008).

Literature References
PubMed ID Title Journal Year
18316480 Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

Zhao, X, Jankovic, V, Gural, A, Huang, G, Pardanani, A, Menendez, S, Zhang, J, Dunne, R, Xiao, A, Erdjument-Bromage, H, Allis, CD, Tempst, P, Nimer, SD

Genes Dev. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created