Reactome | RUNX1 binds PRMT1

RUNX1 binds PRMT1

Stable Identifier

R-HSA-8934742

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RUNX1 forms a complex with protein arginine methyltransferase 1 (PRMT1) in a RNA- and DNA-independent manner. The interaction with PRMT1 involves the C-terminus of RUNX1. Since PRMT1 colocalizes with RUNX1 at RUNX1 target promoters, RUNX1 is shown as part of the RUNX1:CBFB complex (Zhao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18316480	Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity Menendez, S, Tempst, P, Xiao, A, Nimer, SD, Allis, CD, Erdjument-Bromage, H, Zhao, X, Pardanani, A, Jankovic, V, Zhang, J, Dunne, R, Gural, A, Huang, G	Genes Dev.	2008