phenylalanine + pyruvate => 3-(indol-3-yl)pyruvate + alanine

Stable Identifier
R-HSA-893593
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CCBL1 (KAT 1) catalyzes the reaction of phenylalanine and pyruvate to form 3-(indol-3-yl)pyruvate and alanine. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Baran et al. 1994; Han et al. 2009; Rossi et al. 2004). The enzyme's cytosolic localization is inferred from that of recombinant protein overexpressed in transfected cells (Perry et al. 1995).

Literature References
PubMed ID Title Journal Year
15364907 Crystal structure of human kynurenine aminotransferase I

Rossi, F, Han, Q, Li, J, Li, J, Rizzi, M

J Biol Chem 2004
8294935 Purification and characterization of kynurenine aminotransferase I from human brain

Baran, H, Okuno, E, Kido, R, Schwarcz, R

J Neurochem 1994
7883047 Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase

Perry, S, Harries, H, Scholfield, C, Lock, T, King, L, Gibson, G, Goldfarb, P

FEBS Lett 1995
19338303 Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K

Han, Q, Robinson, H, Cai, T, Tagle, DA, Li, J

J Med Chem 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
L-phenylalanine:pyruvate aminotransferase activity of PXLP-KYAT1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created