miR-18a binds RUNX1 mRNA

Stable Identifier
R-HSA-8935930
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Mature single stranded microRNA miR-18a-5p, one of the two products of miR-18a, encoded by the MIR18A gene, binds to the 3'UTR of RUNX1 mRNA, resulting in decreased RUNX1 mRNA and protein levels. As it affects RUNX1 mRNA levels, miR-18a is assumed to function as a component of the endonucleolytic RISC, but it is possible that it additionally functions as a component of the nonendonucleolytic RISC (Miao et al. 2015).

Literature References
PubMed ID Title Journal Year
25452107 MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5

Miao, YS, Zhao, YY, Zhao, LN, Wang, P, Liu, YH, Ma, J, Xue, YX

Cell. Signal. 2015
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