miR-675 binds RUNX1 mRNA

Stable Identifier
R-HSA-8936058
Type
Reaction [binding]
Species
Homo sapiens
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Mature single stranded microRNA miR-675-5p is one of the two products of miR-675, which is produced from a precursor long non-coding RNA H19 (Cai and Cullen 2007). miR-675-5p binds to the 3'UTR of RUNX1 mRNA, resulting in decreased RUNX1 mRNA and protein levels. As it decreases RUNX1 mRNA levels, miR-675 is assumed to function as a component of the endonucleolytic RISC, but it is possible that it additionally functions as a component of the nonendonucleolytic RISC. Levels of miR-675 are increased in gastric cancer (Zhuang et al. 2014).

Literature References
PubMed ID Title Journal Year
24388988 The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

Zhuang, M, Gao, W, Xu, J, Wang, P, Shu, Y

Biochem. Biophys. Res. Commun. 2014
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