Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

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R-HSA-8936621
Type
Reaction [transition]
Species
Homo sapiens
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The WDR5-containing histone methyltransferase MLL complex, recruited to the GP1BA promoter via RUNX1 (and possibly GATA1), methylates histone H3 on dimethylated lysine residue K4 (K5 when taking into account the initiator methionine), producing the H3K4me3 mark. The H3K4me3 mark is characteristic of nucleosome associated with transcriptionally active promoters of megakaryocyte-specific genes (Herglotz et al. 2013).

Literature References
PubMed ID Title Journal Year
22777353 Histone arginine methylation keeps RUNX1 target genes in an intermediate state

Herglotz, J, Kuvardina, ON, Kolodziej, S, Kumar, A, Hussong, H, Grez, M, Lausen, J

Oncogene 2013
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Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
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Orthologous Events
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