AHR:2xHSP90:AIP:PTGES3 binds TCDD

Stable Identifier
R-HSA-8936849
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can control the expression of a diverse set of genes. Two major types of environmental compounds can activate AHR signaling: halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAH) such as benzo(a)pyrene. Unliganded AHR forms a complex in the cytosol with two copies of 90kD heat shock protein (HSP90AB1) (Forsythe et al. 2001), one X-associated protein (AIP) (Meyer et al. 1998), and one p23 molecular chaperone protein (PTGES3) (Nguyen et al. 2012, Beischlag et al. 2008). Here, the binding of TCDD is shown.

Literature References
PubMed ID Title Journal Year
12573486 Functional role of AhR in the expression of toxic effects by TCDD

Mimura, J, Fujii-Kuriyama, Y

Biochim. Biophys. Acta 2003
18540824 The aryl hydrocarbon receptor complex and the control of gene expression

Beischlag, TV, Luis Morales, J, Hollingshead, BD, Perdew, GH

Crit. Rev. Eukaryot. Gene Expr. 2008
11274138 Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

Forsythe, HL, Jarvis, JL, Turner, JW, Elmore, LW, Holt, SE

J Biol Chem 2001
22759865 p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines

Nguyen, PM, Wang, D, Wang, Y, Li, Y, Uchizono, JA, Chan, WK

Biochem. Pharmacol. 2012
7961644 Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors

Ema, M, Ohe, N, Suzuki, M, Mimura, J, Sogawa, K, Ikawa, S, Fujii-Kuriyama, Y

J. Biol. Chem. 1994
9447995 Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity

Meyer, BK, Pray-Grant, MG, Vanden Heuvel, JP, Perdew, GH

Mol. Cell. Biol. 1998
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