Reactome: A Curated Pathway Database

AHR:2xHSP90:AIP:PTGES3 binds TCDD

Stable Identifier
R-HSA-8936849
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can control the expression of a diverse set of genes. Two major types of environmental compounds can activate AHR signaling: halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAH) such as benzo(a)pyrene. Unliganded AHR forms a complex in the cytosol with two copies of 90kD heat shock protein (HSP90AB1) (Forsythe et al. 2001), one X-associated protein (AIP) (Meyer et al. 1998), and one p23 molecular chaperone protein (PTGES3) (Nguyen et al. 2012, Beischlag et al. 2008). Here, the binding of TCDD is shown.

Literature References
Participants
Participant Of
Orthologous Events