AHRR binds ARNT

Stable Identifier
R-HSA-8936851
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The aryl hydrocarbon receptor repressor (AHRR) is predominantly localised in the nucleus of cells (Kanno et al. 2007) and can bind AHR nuclear translocator (ARNT). The resultant AHRR:ARNT complex can compete with AHR:ARNT for binding to the xenobiotic response element (XRE) on target genes such CYP1A1 (Evans et al. 2008, Hahn et al. 2009).

Literature References
PubMed ID Title Journal Year
17980155 Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor

Kanno, Y, Miyama, Y, Takane, Y, Nakahama, T, Inouye, Y

Biochem. Biophys. Res. Commun. 2007
18000031 Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator

Evans, BR, Karchner, SI, Allan, LL, Pollenz, RS, Tanguay, RL, Jenny, MJ, Sherr, DH, Hahn, ME

Mol. Pharmacol. 2008
18848529 Regulation of constitutive and inducible AHR signaling: complex interactions involving the AHR repressor

Hahn, ME, Allan, LL, Sherr, DH

Biochem. Pharmacol. 2009
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