PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter

Stable Identifier
R-HSA-8937022
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
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The histone arginine methyltransferase PRMT6 asymmetrically dimethylates histone H3 on arginine residue R2 (R3 when taking into account the initiator methionine), thus creating the H3R2me2a mark on nucleosomes at the THBS1 gene promoter. Histone H3 arginine methylation by PRMT6 interferes with generation of the activating H3K4me3 mark at the THBS1 gene promoter, thus contributing to transcriptional repression (Michaud-Levesque and Richard 2009).
Literature References
PubMed ID Title Journal Year
19509293 Thrombospondin-1 is a transcriptional repression target of PRMT6

Michaud-Levesque, J, Richard, S

J. Biol. Chem. 2009
Participants
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Output
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as an event of
Catalyst Activity

histone H3 methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm]

Physical Entity
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
Activity
histone H3 methyltransferase activity (GO:0140938)
Orthologous Events
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Bos taurus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Caenorhabditis elegans)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Canis familiaris)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Danio rerio)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Drosophila melanogaster)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Gallus gallus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Mus musculus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Rattus norvegicus)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Sus scrofa)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-08-26)
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