Reactome: A Curated Pathway Database

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

Stable Identifier
R-HSA-8937169
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After ligand binding and activation, the AHR complex translocates to the nucleus by an unknown mechanism (Beischlag et al. 2008) but it has been hypothesised that ligand binding to AHR promoted p23-associated hsp90 complex-mediated interaction of AHR with the nuclear import receptor protein pendulin and subsequent nuclear translocation of the receptor (Kazlauskas et al. 2001).

Literature References
Participants
Participant Of
Orthologous Events