ATAD2 binds ESR1

Stable Identifier
R-HSA-8937369
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATPase family AAA domain-containing protein 2 (ATAD2 aka ANCCA) is a highly conserved protein primarily located in the cell nucleus. Its protein structure consists of two AAA domains and one bromodomain, indicating roles related to genome regulation, such as acting on chromatin structure and function (Caron et al. 2010, Magnani & Lupien 2014). ATAD2 is highly expressed in multiple cancers (Krakstad et al. 2015, Ciro et al. 2009, ) and is a strong predictor of rapid mortality in lung and breast cancers sufferers (Caron et al. 2010). Additionally, ATAD2 functions as a co-activator of the estrogen receptor (ESR1) and the androgen receptor (Zou et al. 2009), implicating it as an oncogenic protein in hormone-related cancers such as breast cancer and prostate cancer (Zou et al. 2007). This reaction shows ATAD2 binding to ESR1.

Literature References
PubMed ID Title Journal Year
19318566 Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer

Zou, JX, Guo, L, Revenko, AS, Tepper, CG, Gemo, AT, Kung, HJ, Chen, HW

Cancer Res. 2009
23684889 Chromatin and epigenetic determinants of estrogen receptor alpha (ESR1) signaling

Magnani, L, Lupien, M

Mol. Cell. Endocrinol. 2014
26308378 ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma

Krakstad, C, Tangen, IL, Hoivik, EA, Halle, MK, Berg, A, Werner, HM, Ræder, MB, Kusonmano, K, Zou, JX, Øyan, AM, Stefansson, I, Trovik, J, Kalland, KH, Chen, HW, Salvesen, HB

Oncotarget 2015
20581866 Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

Caron, C, Lestrat, C, Marsal, S, Escoffier, E, Curtet, S, Virolle, V, Barbry, P, Debernardi, A, Brambilla, C, Brambilla, E, Rousseaux, S, Khochbin, S

Oncogene 2010
17998543 ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification

Zou, JX, Revenko, AS, Li, LB, Gemo, AT, Chen, HW

Proc. Natl. Acad. Sci. U.S.A. 2007
19843847 ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors

Ciró, M, Prosperini, E, Quarto, M, Grazini, U, Walfridsson, J, McBlane, F, Nucifero, P, Pacchiana, G, Capra, M, Christensen, J, Helin, K

Cancer Res. 2009
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created