IL10 positively regulates plasma membrane-associated inflammatory mediators

Stable Identifier
R-HSA-8937654
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

IL10 upregulates monocyte expression of FPR1 (fMLP receptor), PTAFR (PAF receptor), CCR1, CCR2, and CCR5, making them more responsive to chemotactic factors (Andrew et al. 1998, Sozzani et al. 1998, Thivierge et al. 1999) and more susceptible to HIV infection (Andrew et al. 1998, Sozzani et al. 1998).
IL10 enhances activated monocyte expression of the natural antagonists interleukin-1 receptor antagonist (IL1RN) and TNFRSF1B (p75 TNFR) (Cassatella et al 1994, Hart et al. 1996, Joyce & Steer 1996, Linderholm et al. 1996, Dickensheets et al. 1997).

IL10 enhances production of tissue inhibitor of metalloproteinases (TIMP1) and hyaluronectin, which bind and inhibit the angiogenic- and migration-promoting activities of hyaluronic acid (Mertz et al. 1994, Lacraz et al. 1995, Stearns et al. 1999, Girard et al. 1999).

IL10 enhances expression of CD16 and CD64 FcgammaR on monocytes (te Velde et al. 1992, de Waal Malefyt et al. 1993, Calzada-Wack et al. 1996).

Literature References
PubMed ID Title Journal Year
8537680 Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome J. Infect. Dis. 1996
7684412 Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation J. Immunol. 1993
8871669 Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10 J. Immunol. 1996
8734788 Interleukin-10 drives human monocytes to CD16 positive macrophages J. Inflamm. 1996
8742066 IL-4, IL-10 and IFN-gamma have distinct, but interacting, effects on differentiation-induced changes in TNF-alpha and TNF receptor release by cultured human monocytes Cytokine 1996
9794440 STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13 J. Immunol. 1998
9354687 Interleukin-10 upregulates tumor necrosis factor receptor type-II (p75) gene expression in endotoxin-stimulated human monocytes Blood 1997
9918218 Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2/MMP-9 secretion Clin. Cancer Res. 1999
9449724 Interleukin 10 increases CCR5 expression and HIV infection in human monocytes J. Exp. Med. 1998
8063757 Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production J. Biol. Chem. 1994
10092818 Modulation of formyl peptide receptor expression by IL-10 in human monocytes and neutrophils J. Immunol. 1999
1460289 IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10 J. Immunol. 1992
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