IL10 negatively regulates plasma membrane-associated inflammatory mediators

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Homo sapiens
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IL10 modulates the expression of cytokines, soluble mediators and cell surface molecules by cells of myeloid origin, with important consequences for their ability to activate and sustain immune and inflammatory responses. The effects of IL10 on cytokine production and function of human macrophages are generally similar to those on monocytes, although less pronounced (Moore et al. 2001). IL10 inhibits expression of IL1R1 and IL-1RII (de Waal Malefyt et al. 1991, Jenkins et al. 1994, Dickensheets & Donnelly 1997).

Both transcriptional and posttranscriptional mechanisms have been implicated in the inhibitory effects of IL10 on cytokine and chemokine production (Bogdan et al. 1991, Clarke et al. 1998, Brown et al. 1996). IL10 inhibits monocyte expression of MHC class II antigens, ICAM1 (CD54), CD80 (B7), CD86 (B7.2) and FCER2 (CD23), countering the induction of these molecules by IL-4 or IFNgamma (de Waal Malefyt et al. 1991, Ding et al. 1993, Kubin et al. 1994, Willems et al. 1994, Morinobu et al. 1996). Downregulated expression of these molecules significantly decreases the T cell-activating capacity of monocyte APCs (de Waal Malefyt et al. 1991, Fiorentino et al. 1991, Ding et al. 1993).

Literature References
PubMed ID Title Journal Year
7902377 Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation by IFN-gamma or IL-10

de Waal Malefyt, R, Figdor, CG, Huijbens, R, Mohan-Peterson, S, Bennett, B, Culpepper, J, Dang, W, Zurawski, G, de Vries, JE

J. Immunol. 1993
1940369 IL-10 inhibits cytokine production by activated macrophages

Fiorentino, DF, Zlotnik, A, Mosmann, TR, Howard, M, O'Garra, A

J. Immunol. 1991
8102388 Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells

D'Andrea, A, Aste-Amezaga, M, Valiante, NM, Ma, X, Kubin, M, Trinchieri, G

J. Exp. Med. 1993
8946277 IL-10 suppresses cell surface CD23/Fc epsilon RII expression, not by enhancing soluble CD23 release, but by reducing CD23 mRNA expression in human monocytes

Morinobu, A, Kumagai, S, Yanagida, H, Ota, H, Ishida, H, Matsui, M, Yodoi, J, Nakao, K

J. Clin. Immunol. 1996
1940799 Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

de Waal Malefyt, R, Abrams, J, Bennett, B, Figdor, CG, de Vries, JE

J. Exp. Med. 1991
7687627 IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression

Ding, L, Linsley, PS, Huang, LY, Germain, RN, Shevach, EM

J. Immunol. 1993
8186324 The effects of interleukin-10 on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils

Jenkins, JK, Malyak, M, Arend, WP

Lymphokine Cytokine Res. 1994
7512027 Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes

Willems, F, Marchant, A, Delville, JP, Gérard, C, Delvaux, A, Velu, T, de Boer, M, Goldman, M

Eur. J. Immunol. 1994
7516408 Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells

Kubin, M, Kamoun, M, Trinchieri, G

J. Exp. Med. 1994
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