PTPN11 dephosphorylates RUNX1

Stable Identifier
R-HSA-8937767
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Based on mouse studies, PTPN11 (SHP2) protein tyrosine phosphatase dephosphorylates SRC-phosphorylated RUNX1 (Huang et al. 2012).

Literature References
PubMed ID Title Journal Year
22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

Huang, H, Woo, AJ, Waldon, Z, Schindler, Y, Moran, TB, Zhu, HH, Feng, GS, Steen, H, Cantor, AB

Genes Dev. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of p-7Y-RUNX1:PTPN11 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created