Reactome | p-Y-RUNX3 [cytosol]

p-Y-RUNX3 [cytosol]

Stable Identifier

R-HSA-8937805

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        SRC phosphorylates RUNX3 (Homo sapiens)
        
        p-Y-RUNX3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13761 RUNX3

Gene Names

RUNX3, AML2, CBFA3, PEBP2A3

Chain

chain:1-415

Reference Genes

BioGPS Gene:864 RUNX3

COSMIC (genes):RUNX3 RUNX3

CTD Gene:864 RUNX3

dbSNP Gene:864 RUNX3

ENSEMBL:ENSG00000020633 RUNX3

ENSEMBL_homo_sapiens_GENE:ENSG00000020633.19 RUNX3

HGNC:10473 RUNX3

KEGG Gene (Homo sapiens):864 RUNX3

Monarch:864 RUNX3

NCBI Gene:864 RUNX3

OMIM:600210 RUNX3

UCSC:Q13761 RUNX3

Reference Transcript

Other Identifiers

106_at

11740486_a_at

11743428_a_at

11752954_x_at

11755054_x_at

16683624

204197_PM_s_at

204197_s_at

204198_PM_s_at

204198_s_at

2401988

2401990

2401992

2401993

2401995

2401996

2401997

2402004

2402008

2402013

2402016

2402017

2402018

2402026

2402027

2402028

2402029

7913805

864

A_23_P51231

A_33_P3221748

GE60398

GE84493

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001222

GO:0001503

GO:0002062

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006468

GO:0007155

GO:0016513

GO:0030097

GO:0030154

GO:0030182

GO:0036211

GO:0043226

GO:0043231

GO:0043371

GO:0043378

GO:0043565

GO:0045595

GO:0045786

GO:0045893

GO:0048856

GO:0048935

GO:0050680

GO:0071559

GO:0140110

GO:1990837

HMNXSV003032604

Hs.170019.0.S1_3p_a_at

Hs.170019.1.S1_3p_a_at

Hs.170019.1.S1_3p_at

Hs.170019.1.S1_3p_x_at

ILMN_1751839

ILMN_1787461

PH_hs_0010147

TC01002370.hg

TC01005339.hg

TC01005340.hg

TC01005341.hg

Z35278_at

g4757917_3p_a_at

Participates

as an output of

SRC phosphorylates RUNX3 (Homo sapiens)

Other forms of this molecule

RUNX3 [nucleoplasm]

RUNX3 [cytosol]

Ac-K94,K171-RUNX3 [nucleoplasm]

PolyUb-K94,K148-RUNX3 [cytosol]

PolyUb-K94,K148-RUNX3 [nucleoplasm]

PolyUb-RUNX3 [nucleoplasm]

Inferred To

phospho-RunxA [cytosol] (Drosophila melanogaster)

Homologues of p-Y-RUNX3 [cytosol] (Drosophila melanogaster)

phospho-run [cytosol] (Drosophila melanogaster)

phospho-Runx3 [cytosol] (Mus musculus)

phospho-p-Y-RUNX3 [cytosol] (Bos taurus)

phospho-p-Y-RUNX3 [cytosol] (Caenorhabditis elegans)

phospho-p-Y-RUNX3 [cytosol] (Canis familiaris)

phospho-p-Y-RUNX3 [cytosol] (Danio rerio)

phospho-p-Y-RUNX3 [cytosol] (Gallus gallus)

phospho-p-Y-RUNX3 [cytosol] (Rattus norvegicus)

phospho-p-Y-RUNX3 [cytosol] (Sus scrofa)

phospho-RunxB [cytosol] (Drosophila melanogaster)

phospho-lz [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001307601.1, NP_004341.1, XP_005246081.1, NP_001026850.1

OpenTargets

ENSG00000020633

GeneCards

Q13761

HPA

ENSG00000020633-RUNX3

Ensembl

ENST00000399916, ENST00000308873, ENSP00000308051, ENSG00000020633, ENST00000338888, ENSP00000343477, ENSP00000382800

PRO

Q13761

Pharos - Targets

Q13761

PDB

5W69

HMDB Protein

HMDBP14478

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.656	14
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.656	12
UniProt:P25440 BRD2	1	BRD2 [nucleoplasm] (R-HSA-8951979)	0.599	8
UniProt:Q04724 TLE1	2	Ub-TLE1 [nucleoplasm] (R-HSA-3322369) TLE1 [nucleoplasm] (R-HSA-212327)	0.593	3
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.558	9
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.558	7
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.499	5
UniProt:Q13951 CBFB	1	CBFB [nucleoplasm] (R-HSA-8865293)	0.499	3
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.462	8

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