Reactome | YAF2 [nucleoplasm]

YAF2 [nucleoplasm]

Stable Identifier

R-HSA-8937973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

YY1-associated factor 2, YAF2_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
      - E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
        
        E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
      - E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        YAF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IY57 YAF2

Gene Names

YAF2

Chain

chain:1-180

Reference Genes

BioGPS Gene:10138 YAF2

COSMIC (genes):YAF2 YAF2

CTD Gene:10138 YAF2

dbSNP Gene:10138 YAF2

ENSEMBL:ENSG00000015153 YAF2

HGNC:17363 YAF2

KEGG:hsa:10138 YAF2

Monarch:10138 YAF2

NCBI Gene:10138 YAF2

OMIM:607534 YAF2

UCSC:Q8IY57 YAF2

Reference Transcript

Participates

as a component of

PRC1.6 (PCGF6:L3MBTL2:RING1,RNF2:YAF2) [nucleoplasm] (Homo sapiens)

as a member of

RYBP,YAF2 [nucleoplasm] (Homo sapiens)

Inferred To

RYBP [nucleoplasm] (Drosophila melanogaster)

Yaf2 [nucleoplasm] (Mus musculus)

Yaf2 [nucleoplasm] (Rattus norvegicus)

YAF2 [nucleoplasm] (Bos taurus)

YAF2 [nucleoplasm] (Canis familiaris)

YAF2 [nucleoplasm] (Gallus gallus)

YAF2 [nucleoplasm] (Sus scrofa)

tag-294 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001177909.1, NP_001177906.1, NP_001177908.1, NP_005739.2

OpenTargets

ENSG00000015153

ENSEMBL

ENSG00000015153, ENSP00000439256, ENST00000555248, ENSP00000370167, ENSP00000328004, ENST00000380790, ENST00000327791, ENSP00000451626, ENST00000534854

HPA

ENSG00000015153-YAF2

GeneCards

YAF2

PRO

Q8IY57

Pharos - Targets

Q8IY57

GlyGen

Q8IY57

PDB

2D9G

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.788	8
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.788	8
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.788	7
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.725	7
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.643	3
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.643	6
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.643	7
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.593	4
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.527	4
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.527	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	3
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.527	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.527	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.527	2

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