NR4A3 gene expression is stimulated by RUNX1:CBFB

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R-HSA-8938034
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Reaction [omitted]
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Homo sapiens
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Binding of the RUNX1:CBFB complex to the NR4A3 gene promoter stimulates NR4A3 gene transcription, leading to reduction in the clonogenic potential of hematopoietic progenitors. RUNX1 mutants associated with familial platelet disorders (FPD) and acute myeloid leukemia (AML) are unable to transactivate the NR4A3 gene (Bluteau et al. 2011).

Literature References
PubMed ID Title Journal Year
21725049 Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia

Bluteau, D, Gilles, L, Hilpert, M, Antony-Debré, I, James, C, Debili, N, Camara-Clayette, V, Wagner-Ballon, O, Cordette-Lagarde, V, Robert, T, Ripoche, H, Gonin, P, Swierczek, S, Prchal, J, Vainchenker, W, Favier, R, Raslova, H

Blood 2011
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