SERPINB13 binds cathepsin L

Stable Identifier
R-HSA-8938108
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SERPINB13 binds the lysosomal cystein protease cathepsin L and inhibits its catalytic activity (Jayakumar et al. 2003, Welss et al. 2003). It is uncertain whether SERPINB13 functions in the lysosomes or exclusively in the cytosol, where it would inhibit the enzymatic activity of ectopic cathepsin L (Welss et al. 2003).

Literature References
PubMed ID Title Journal Year
12504904 Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis

Jayakumar, A, Kang, Y, Frederick, MJ, Pak, SC, Henderson, Y, Holton, PR, Mitsudo, K, Silverman, GA, EL-Naggar, AK, Brömme, D, Clayman, GL

Arch. Biochem. Biophys. 2003
12809493 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

Welss, T, Sun, J, Irving, JA, Blum, R, Smith, AI, Whisstock, JC, Pike, RN, von Mikecz, A, Ruzicka, T, Bird, PI, Abts, HF

Biochemistry 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created