PF4 gene transcription is stimulated by RUNX1:CBFB

Stable Identifier
R-HSA-8938174
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of the RUNX1:CBFB complex to the promoter of the PF4 gene stimulates transcription of PF4. The PF4 gene encodes Platelet factor 4, a protein stored in platelet alpha granules. Deficiency of alpha granule proteins, including PF4, is the cause of gray platelet syndrome. PF4 deficiency can be caused by RUNX1 haploinsuficiency (Aneja et al. 2011).

Literature References
PubMed ID Title Journal Year
21129147 Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4

Aneja, K, Jalagadugula, G, Mao, G, Singh, A, Rao, AK

J. Thromb. Haemost. 2011
Participants
Participant Of
This event is regulated
Authored
Reviewed
Created