Binding of the RUNX1:CBFB complex associated with the histone acetyltransferase (HAT) CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), stimulates CSF2 transcription. HAT activity of CREBBP is required for RUNX1-mediated stimulation of CSF2 expression. GM-CSF is involved in myeloid cell differentiation (Oakford et al. 2010). It has not been fully elucidated how recruitment of the SWI/SNF complex to the CSF2 promoter by RUNX1 affects CSF2 transcription (Bakshi et al. 2010).