Mouse Vnn1 has been shown to be GPI-anchored to the outer face of the plasma membrane. Sequence motifs conserved with human VNN1 and VNN2 supports the inference that the human proteins are similarly anchored (Aurand-Lions et al. 1996; Naquet et al. 2020), so the enzymes are annotated as acting on extracellular panthetheine to generate extracellular PanK and 2AET.
Kerr, EW, Leonardi, R, Naquet, P, Vickers, SD
Pitari, G, Duprè, S, Barra, D, Maras, B
Imhof, BA, Aurrand-Lions, M, Zakharyev, VM, Bazin, H, Galland, F, Naquet, P
pantetheine hydrolase activity of VNN1,VNN2 [plasma membrane]
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