RMB14 binds RUNX2

Stable Identifier
R-HSA-8938356
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RBM14 (CoAA) binds RUNX2. This interaction involves the C-terminus of RBM14 and the Runt domain of RUNX2. It has not been examined whether RBM14 interacts with RUNX2 alone or in the context of the RUNX2:CBFB complex. Formation of the RUNX2:RBM14 complex prevents binding of RUNX2 to its target promoters and thus interferes with activation of RUNX2 target genes. RBM14 is frequently overexpressed in osteosarcoma (Li et al. 2009).

Literature References
PubMed ID Title Journal Year
19585539 Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

Li, X, Hoeppner, LH, Jensen, ED, Gopalakrishnan, R, Westendorf, JJ

J. Cell. Biochem. 2009
Participants
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