RNF144A binds PRKDC and Ubiquitin:UBE2L3

Stable Identifier
R-HSA-8938770
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The ubiquitin E3 ligase RNF144A located on endosomal membranes (Ho et al. 2015) binds the catalytic subunit of DNA-dependent protein kinase (PRKDC, DNA-PKcs) and the E2-ubiquitin conjugate UBE2L3:Ubiquitin (UBCH7:Ubiquitin) located in the cytoplasm (Ho et al. 2014).

Literature References
PubMed ID Title Journal Year
26216882 Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain

Ho, SR, Lee, YJ, Lin, WC

J. Biol. Chem. 2015
24979766 RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage

Ho, SR, Mahanic, CS, Lee, YJ, Lin, WC

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
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