RNF144A binds PRKDC and Ubiquitin:UBE2L3

Stable Identifier
R-HSA-8938770
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The ubiquitin E3 ligase RNF144A located on endosomal membranes (Ho et al. 2015) binds the catalytic subunit of DNA-dependent protein kinase (PRKDC, DNA-PKcs) and the E2-ubiquitin conjugate UBE2L3:Ubiquitin (UBCH7:Ubiquitin) located in the cytoplasm (Ho et al. 2014).

Literature References
PubMed ID Title Journal Year
26216882 Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain

Ho, SR, Lee, YJ, Lin, WC

J. Biol. Chem. 2015
24979766 RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage

Ho, SR, Mahanic, CS, Lee, YJ, Lin, WC

Proc. Natl. Acad. Sci. U.S.A. 2014
Participants
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