Reactome | CSTF2T [nucleoplasm]

CSTF2T [nucleoplasm]

Stable Identifier

R-HSA-8938786

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cleavage stimulation factor subunit 2 tau variant, CSTFT_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2T [nucleoplasm] (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2T [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2T [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CstF [nucleoplasm] (Homo sapiens)
        
        CSTF2,CSTF2T [nucleoplasm] (Homo sapiens)
        
        CSTF2T [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0L4 CSTF2T

Gene Names

CSTF2T, KIAA0689

Chain

chain:1-616

Reference Genes

BioGPS Gene:23283 CSTF2T

COSMIC (genes):CSTF2T CSTF2T

CTD Gene:23283 CSTF2T

dbSNP Gene:23283 CSTF2T

ENSEMBL:ENSG00000177613 CSTF2T

HGNC:17086 CSTF2T

KEGG Gene (Homo sapiens):23283 CSTF2T

Monarch:23283 CSTF2T

NCBI Gene:23283 CSTF2T

OMIM:611968 CSTF2T

UCSC:Q9H0L4 CSTF2T

Reference Transcript

RefSeq:NM_015235.2 CSTF2T

Other Identifiers

0000610168

11724750_at

11758594_s_at

16714381

212901_s_at

212905_at

23283

3289637

3289638

3289639

3289640

3289641

3289642

3289643

3289644

3289645

3289646

3289647

3289648

3289649

3289650

3289651

41248_at

7933659

A_23_P12730

A_24_P941051

GE53391

GE80165

GO:0000398

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005847

GO:0006369

GO:0006397

GO:0008150

GO:0009058

GO:0031124

GO:0032991

GO:0034641

GO:0043226

GO:0043231

GO:0098789

Hs.21992.1.S1_3p_a_at

Hs.21992.1.S2_3p_at

ILMN_1807515

PH_hs_0001917

TC10001297.hg

Participant Of

hasMember

CSTF2,CSTF2T [nucleoplasm]

Inferred To

CSTF2 [nucleoplasm] (Gallus gallus)

cstf2 [nucleoplasm] (Danio rerio)

cstf2 [nucleoplasm] (Xenopus tropicalis)

Homologues of CSTF2T [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CSTF2T [nucleoplasm] (Schizosaccharomyces pombe)

cpf-2 [nucleoplasm] (Caenorhabditis elegans)

RNA15 [nucleoplasm] (Saccharomyces cerevisiae)

ctf1 [nucleoplasm] (Schizosaccharomyces pombe)

Cstf2t [nucleoplasm] (Mus musculus)

Cstf2t [nucleoplasm] (Rattus norvegicus)

CSTF2T [nucleoplasm] (Canis familiaris)

CSTF2T [nucleoplasm] (Dictyostelium discoideum)

CSTF2T [nucleoplasm] (Schizosaccharomyces pombe)

CSTF2T [nucleoplasm] (Sus scrofa)

CstF64 [nucleoplasm] (Drosophila melanogaster)

PTI1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_056050.1

OpenTargets

ENSG00000177613

GeneCards

Q9H0L4

HPA

ENSG00000177613-CSTF2T

Ensembl

ENSG00000177613, ENST00000331173, ENSP00000332444

PRO

Q9H0L4

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14964 HGS	2	HGS [phagocytic vesicle lumen] (R-HSA-9635660) HGS [cytosol] (R-HSA-182954)	0.556	3
UniProt:Q9UMD9 COL17A1	48	GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173084) GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173102) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173190) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173237) 3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173184) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173264) COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172232) 3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172934) 3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172989) 3x4Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173162) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173230) 5Hyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173044) 3x4Hyp-GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471866) 5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471851) 3x4Hyp-3Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471867) 3x4Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471913) 3x4Hyp-3Hyp-5Hyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471897) COL17A1(?-1497) [extracellular region] (R-HSA-2471870) GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471903) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471916) 3x4Hyp-COL17A1(?-1497) [extracellular region] (R-HSA-2471874) 3x4Hyp-3Hyp-GalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471859) GlcGalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471862) 3x4Hyp-GlcGalHyl-COL17A1(?-1497) [extracellular region] (R-HSA-2471861) COL17A1(1-?) [plasma membrane] (R-HSA-2471864) 3x4Hyp-GlcGalHyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471848) 3x4Hyp-GalHyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471912) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471849) 5Hyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471871) 3x4Hyp-3Hyp-COL17A1(1-?) [plasma membrane] (R-HSA-2471852) COL17A1(1-1497) [plasma membrane] (R-HSA-445994) GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192833) GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192832) 3x4Hyp-GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192834) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192837) 3x4Hyp-COL17A1(1-1497) [plasma membrane] (R-HSA-2192836) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192839) 3x4Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192841) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192840) 3x4Hyp-3Hyp-COL17A1(1-1497) [plasma membrane] (R-HSA-2192843) 5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192842) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192831) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471893) GlcGalHyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471892) GalHyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471863) 3x4Hyp-5Hyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471841) 3x4Hyp-COL17A1(1-?) [plasma membrane] (R-HSA-2471872) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-?) [plasma membrane] (R-HSA-2471853)	0.556	3