RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3

Stable Identifier
R-HSA-8938829
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The ubiquitin E3 ligase RNF152 located in the lysosomal membrane (Zhang et al. 2010) binds GDP-bound RRAGA and the E2-ubiquitin conjugate UBE2N:Ubiquitin prior to ubiquitinating RRAGA (Deng et al. 2015), RNF152, like many E3 ligases, can also autoubiquitinate (Zhang et al. 2010).

Literature References
PubMed ID Title Journal Year
25936802 The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation

Deng, L, Jiang, C, Chen, L, Jin, J, Wei, J, Zhao, L, Chen, M, Pan, W, Xu, Y, Chu, H, Wang, X, Ge, X, Li, D, Liao, L, Liu, M, Li, L, Wang, P

Mol. Cell 2015
21203937 RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities

Zhang, S, Wu, W, Wu, Y, Zheng, J, Suo, T, Tang, H, Tang, J

Protein Cell 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed