CDK6 binds RUNX1

Stable Identifier
R-HSA-8938853
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CDK6 binds to the Runt domain of RUNX1 and interferes with RUNX1 binding to DNA and transcription co-factors. Formation of the RUNX1:CBFB complex does not affect the ability of CDK6 to interact with RUNX1. Neither the catalytic activity nor the cyclin-binding activity of CDK6 are required for its association with RUNX1 (Fujimoto et al. 2007).

Literature References
PubMed ID Title Journal Year
17431401 Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction

Fujimoto, T, Anderson, K, Jacobsen, SE, Nishikawa, SI, Nerlov, C

EMBO J. 2007
Participants
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Orthologous Events
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