CCND3,(CCND1,CCND2) binds RUNX1

Stable Identifier
R-HSA-8938867
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cyclin D3 (CCND3) binds to the runt domain and the activation domain (AD) of RUNX1, thus inhibiting RUNX1 association with CBFB and RUNX1 binding to DNA. Based on in vitro studies, cyclins D1 (CCND1) and D2 (CCND2) can also bind to RUNX1 (Peterson et al. 2005).
Literature References
PubMed ID Title Journal Year
16287839 The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3

Boyapati, A, Peterson, LF, Iwama, A, Tsai, S, Ranganathan, V, Zhang, DE, Tenen, DG

Mol. Cell. Biol. 2005
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