CCND3,(CCND1,CCND2) binds RUNX1

Stable Identifier
R-HSA-8938867
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cyclin D3 (CCND3) binds to the runt domain and the activation domain (AD) of RUNX1, thus inhibiting RUNX1 association with CBFB and RUNX1 binding to DNA. Based on in vitro studies, cyclins D1 (CCND1) and D2 (CCND2) can also bind to RUNX1 (Peterson et al. 2005).

Literature References
PubMed ID Title Journal Year
16287839 The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3

Peterson, LF, Boyapati, A, Ranganathan, V, Iwama, A, Tenen, DG, Tsai, S, Zhang, DE

Mol. Cell. Biol. 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created