RUNX1 binds ELF1

Stable Identifier
R-HSA-8938913
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The RUNX1:CBFB complex binds to ELF1 (MEF), a member of the ETS family of transcription factors (Mao et al. 1999, Cho et al. 2004). The interaction involves the ETS-interacting subdomain (EID) in the C-terminal portion of the RUNX1 Runt domain and a region of ELF1 that is N-terminal to its ETS domain. ELF1 does not directly interact with CBFB (Mao et al. 1999).

Literature References
PubMed ID Title Journal Year
14970218 Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene

Cho, JY, Akbarali, Y, Zerbini, LF, Gu, X, Boltax, J, Wang, Y, Oettgen, P, Zhang, DE, Libermann, TA

J. Biol. Chem. 2004
10207087 Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

Mao, S, Frank, RC, Zhang, J, Miyazaki, Y, Nimer, SD

Mol. Cell. Biol. 1999
Participants
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