RUNX1 binds ELF2

Stable Identifier
R-HSA-8938930
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The RUNX1:CBFB complex binds to ELF2 (NERF), a member of the ETS family of transcription factors. The interaction involves a basic amino acid region upstream of the ETS domain of ELF2 and the runt domain of RUNX1 (Cho et al. 2004).

Literature References
PubMed ID Title Journal Year
14970218 Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene

Cho, JY, Akbarali, Y, Zerbini, LF, Gu, X, Boltax, J, Wang, Y, Oettgen, P, Zhang, DE, Libermann, TA

J. Biol. Chem. 2004
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created