RUNX1 and ELF1 bind the IL3 gene promoter

Stable Identifier
R-HSA-8938938
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX1 and ELF1 bind the IL3 gene promoter
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RUNX1 (AML1) and ELF1 (MEF) bind to adjacent RUNX1- and ETS- response elements in the promoter of the IL3 gene, encoding interleukin-3. While RUNX1 and ELF1 can independently activate the IL3 gene transcription, formation of the complex between RUNX1 and ELF1 has a synergistic effect on IL3 expression (Mao et al. 1999).
Literature References
PubMed ID Title Journal Year
10207087 Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

Miyazaki, Y, Zhang, J, Nimer, SD, Mao, S, Frank, RC

Mol. Cell. Biol. 1999
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Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-14)
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