RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter

Stable Identifier
R-HSA-8938965
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The RUNX1 response element in the promoter of the BLK gene, encoding B cell tyrosine kinase BLK, is adjacent to the ETS response element as well as the PAX5 (BSAP) response element. The RUNX1:CBFB complex can bind to the ETS family transcription factors ELF1 or ELF2, and this complex can bind to RUNX1 and ETS response elements in the BLK promoter (Cho et al. 2004). RUNX1 can also form a complex with PAX5 (BSAP), and this complex can bind to RUNX1 and PAX5 response elements in the BLK promoter (Libermann et al. 1999). It is not known whether a larger complex, consisting of ELF1 or ELF2, the RUNX1:CBFB complex and PAX5 is formed and if ELF1/ELF2, RUNX1 and PAX5 can simultaneously reside at the BLK promoter. PAX5 is known to contain and ETS binding region and it is possible that it can, through this region, interact with ELF1 and ELF2 (Cho et al. 2004).

Literature References
PubMed ID Title Journal Year
10207087 Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

Mao, S, Frank, RC, Zhang, J, Miyazaki, Y, Nimer, SD

Mol. Cell. Biol. 1999
10455134 AML1 (CBFalpha2) cooperates with B cell-specific activating protein (BSAP/PAX5) in activation of the B cell-specific BLK gene promoter

Libermann, TA, Pan, Z, Akbarali, Y, Hetherington, CJ, Boltax, J, Yergeau, DA, Zhang, DE

J. Biol. Chem. 1999
14970218 Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene

Cho, JY, Akbarali, Y, Zerbini, LF, Gu, X, Boltax, J, Wang, Y, Oettgen, P, Zhang, DE, Libermann, TA

J. Biol. Chem. 2004
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