ESR-mediated signaling

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R-HSA-8939211
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Pathway
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Homo sapiens
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Estrogens are a class of hormones that play a role in physiological processes such as development, reproduction, metabolism of liver, fat and bone, and neuronal and cardiovascular function (reviewed in Arnal et al, 2017; Haldosen et al, 2014). Estrogens bind estrogen receptors, members of the nuclear receptor superfamily. Ligand-bound estrogen receptors act as nuclear transcription factors to regulate expression of genes that control cellular proliferation and differentiation, among other processes, but also play a non-genomic role in rapid signaling from the plasma membrane (reviewed in Hah et al, 2014;Schwartz et al, 2016).

Literature References
PubMed ID Title Journal Year
23810978 Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells

Hah, N, Kraus, WL

Mol. Cell. Endocrinol. 2014
28539435 Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications

Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J

Physiol. Rev. 2017
23954741 Estrogen receptor beta in breast cancer

Haldosén, LA, Zhao, C, Dahlman-Wright, K

Mol. Cell. Endocrinol. 2014
27288742 Rapid steroid hormone actions via membrane receptors

Schwartz, N, Verma, A, Bivens, CB, Schwartz, Z, Boyan, BD

Biochim. Biophys. Acta 2016
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