RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

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R-HSA-8939246
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Pathway
Species
Homo sapiens
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The RUNX1:CBFB complex regulates expression of genes involved in differentiation of myeloid progenitors which can commit to hematopoietic lineages that lead to generation of platelets, erythrocytes, leukocytes or monocytes.
The RUNX1:CBFB complex recruits histone acetyltransferase CREBBP (CBP) to the promoter of the CSF2 gene, encoding Granulocyte-macrophage colony stimulating factor (GM-CSF), thus inducing GM-CSF expression (Oakford et al. 2010). GM-CSF induces growth, differentiation and survival of macrophages, granulocytes, erythrocytes and megakaryocytes from myeloid progenitors (Barreda et al. 2004).
The RUNX1:CBFB complex directly stimulates transcription of the LGALS3 gene, encoding galectin-3 (Zhang et al. 2009). Galectin-3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000).
The PRKCB gene, encoding protein kinase C-beta, which regulates apoptosis of myeloid cells, is directly transactivated by the RUNX1:CBFB complex (Hu et al. 2004).

Literature References
PubMed ID Title Journal Year
10816326 GALECTIN-3 expression in differentiating human myeloid cells

Le Marer, N

Cell Biol. Int. 2000
14561740 A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene

Hug, BA, Ahmed, N, Robbins, JA, Lazar, MA

J. Biol. Chem. 2004
20439113 Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1

Oakford, PC, James, SR, Qadi, A, West, AC, Ray, SN, Bert, AG, Cockerill, PN, Holloway, AF

Leuk. Res. 2010
19020999 RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors

Zhang, HY, Jin, L, Stilling, GA, Ruebel, KH, Coonse, K, Tanizaki, Y, Raz, A, Lloyd, RV

Endocrine 2009
15062647 Regulation of myeloid development and function by colony stimulating factors

Barreda, DR, Hanington, PC, Belosevic, M

Dev. Comp. Immunol. 2004
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