RUNX1 regulates transcription of genes involved in interleukin signaling

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R-HSA-8939247
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Pathway
Species
Homo sapiens
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The RUNX1:CBFB complex regulates transcription of at least a couple of genes involved in interleukin signaling. The LIFR gene, a direct transcriptional target of the RUNX1:CBFB complex (Qadi et al. 2016), encodes the receptor for the leukemia inhibitory factor (LIF), a member of the interleukin-6 family. LIFR is implicated in hematopoiesis, embryo implantation, placental formation and nervous system development (Nicola et al. 2015). In association with its co-activator ELF1, the RUNX1:CBFB complex stimulates transcription of the IL3 gene, encoding interleukin-3 (Mao et al. 1999).

Literature References
PubMed ID Title Journal Year
26187859 Leukemia inhibitory factor (LIF)

Nicola, NA, Babon, JJ

Cytokine Growth Factor Rev. 2015
10207087 Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias

Mao, S, Frank, RC, Zhang, J, Miyazaki, Y, Nimer, SD

Mol. Cell. Biol. 1999
26060100 The Leukemia Inhibitory Factor Receptor Gene Is a Direct Target of RUNX1

Qadi, AA, Taberlay, PC, Phillips, JL, Young, A, West, AC, Brettingham-Moore, KH, Dickinson, JL, Holloway, AF

J. Cell. Biochem. 2016
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