RUNX1 regulates transcription of genes involved in WNT signaling

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Homo sapiens
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The RUNX1:CBFB complex directly regulates transcription of at least two components of WNT signaling. In association with its co-factor FOXP3, the RUNX1:CBFB complex stimulates transcription of the RSPO3 gene, encoding a WNT ligand that is implicated as a breast cancer oncogene (Recouvreux et al. 2016). In association with the activated estrogen receptor alpha (ESR1), the RUNX1:CBFB complex stimulates the expression of AXIN1, which functions as a regulator of WNT signaling (Stender et al. 2010).

Literature References
PubMed ID Title Journal Year
26735887 RUNX1 and FOXP3 interplay regulates expression of breast cancer related genes

Recouvreux, MS, Grasso, EN, Echeverria, PC, Rocha-Viegas, L, Castilla, LH, Schere-Levy, C, Tocci, JM, Kordon, EC, Rubinstein, N

Oncotarget 2016
20547749 Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

Stender, JD, Kim, K, Charn, TH, Komm, B, Chang, KC, Kraus, WL, Benner, C, Glass, CK, Katzenellenbogen, BS

Mol. Cell. Biol. 2010
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