RNF181 polyubiquinates BCL10

Stable Identifier
R-HSA-8939335
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The ubiquitin E3 ligase RNF181 transfers ubiquitin from the E2-ubiquitin conjugate (UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2B, or UBE2N) to BCL10 (Pedersen et al. 2015). RNF181, which can interact with CARD11, appears to act on BCL10 before BCL10 is recruited to activated (phosphorylated) CARD11. The resulting lysine-48 polyubiquitinated BCL10 is degraded by the proteasome, resulting in attenuation of T cell receptor signaling downstream of CARD11 (Pedersen et al. 2015).

Literature References
PubMed ID Title Journal Year
26711259 Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181

Pedersen, SM, Chan, W, Jattani, RP, Mackie, dS, Pomerantz, JL

Mol. Cell. Biol. 2016
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RNF181:BCL10:Ub:E2 [cytoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created