ITGBL1 gene expression is stimulated by RUNX2

Stable Identifier
R-HSA-8939829
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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ITGBL1 gene expression is stimulated by RUNX2
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Binding of RUNX2, presumably associated with CBFB, to RUNX2 response elements in the promoter of the ITGBL1 gene stimulates ITGBL1 transcription. ITGBL1 encodes Integrin beta-like protein 1, which is implicated in regulation of TGF-beta signaling and RUNX2-induced bone metastasis of breast cancer (Li et al. 2015).
Literature References
PubMed ID Title Journal Year
26060017 ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway

Li, XQ, Feng, YM, Liu, PF, Kong, PZ, Sun, Y, Li, DM, Wang, QS, Du, X

Cancer Res. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX2:CBFB:ITGBL1 gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX2:CBFB [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-21)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-21)
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