RUNX2:CBFB binds the MMP13 gene promoter

Stable Identifier
R-HSA-8940001
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2:CBFB binds the MMP13 gene promoter
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AKT-mediated phosphorylation of RUNX2 increases affinity of the RUNX2:CBFB complex for the promoter of the MMP13 gene, encoding Colagenase-3 (Matrix metalloproteinase-13) (Pande et al. 2013).
Literature References
PubMed ID Title Journal Year
23389849 Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells

van Wijnen, AJ, Browne, G, Lian, JB, Padmanabhan, S, Stein, JL, Stein, GS, Pande, S, Zaidi, SK

J. Cell. Physiol. 2013
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Authored
Orlic-Milacic, M  (2016-09-22)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-22)
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