Reactome: A Curated Pathway Database

FOLR2 binds FOLA

Stable Identifier
R-HSA-8940134
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The folate receptor beta (FOLR2, FBP) (Ratnam et al. 1989) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). Antifolates are folate analogues that inhibit vitamin B9 (folic acid)-using cellular enzymes are used in the treatment of cancer and inflammatory diseases. Targeting FOLR2 may be a way to investigate novel folate-based drugs in the treatment of these diseases (Wibowo et al. 2013).

Literature References
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Orthologous Events