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IL36RN [extracellular region]
Stable Identifier
R-HSA-8940995
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-36 receptor antagonist protein, I36RA_HUMAN, IL36-RA
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-36 pathway (Homo sapiens)
IL36 binds IL1RL2 (Homo sapiens)
IL36RN [extracellular region] (Homo sapiens)
IL36:IL1RL2 binds IL1RAP-1 (Homo sapiens)
IL36RN,IL1F10:IL1RL2 [plasma membrane] (Homo sapiens)
IL36RN, IL1F10 [extracellular region] (Homo sapiens)
IL36RN [extracellular region] (Homo sapiens)
IL36RN, IL1F10 bind IL1RL2 (Homo sapiens)
IL36RN, IL1F10 [extracellular region] (Homo sapiens)
IL36RN [extracellular region] (Homo sapiens)
IL36RN,IL1F10:IL1RL2 [plasma membrane] (Homo sapiens)
IL36RN, IL1F10 [extracellular region] (Homo sapiens)
IL36RN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBH0 IL36RN
Gene Names
IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, UNQ1896/PRO4342
Chain
initiator methionine:, chain:2-155
Reference Genes
BioGPS Gene:26525 IL36RN
COSMIC (genes):IL36RN IL36RN
CTD Gene:26525 IL36RN
dbSNP Gene:26525 IL36RN
ENSEMBL:ENSG00000136695 IL36RN
HGNC:15561 IL36RN
KEGG:hsa:26525 IL36RN
Monarch:26525 IL36RN
NCBI Gene:26525 IL36RN
OMIM:605507 IL36RN
UCSC:Q9UBH0 IL36RN
Reference Transcript
RefSeq:NM_173170.1 IL36RN
RefSeq:NM_012275.2 IL36RN
Other Identifiers
11732733_a_at
11732734_a_at
11735417_a_at
16884607
222223_PM_s_at
222223_s_at
2501162
2501163
2501165
2501166
2501167
2501169
2501170
2501171
2501172
2501173
2501174
2501175
2501177
26525
8044552
84883_at
A_14_P124879
A_23_P39856
A_24_P68783
GE80302
GO:0001960
GO:0002376
GO:0002437
GO:0005125
GO:0005149
GO:0005152
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0006954
GO:0006955
GO:0007165
GO:0019732
GO:0032689
GO:0032700
GO:0032715
GO:0045087
GO:0048018
GO:0071222
GO:0098542
GO:0098772
HMNXSV003001084
HMNXSV003019467
Hs.207224.1.S1_3p_a_at
ILMN_1804901
PH_hs_0040322
TC02000717.hg
p9958
Participates
as a member of
IL36RN, IL1F10 [extracellular region] (Homo sapiens)
This entity regulates
Negatively
IL36 binds IL1RL2
(Homo sapiens)
Inferred To
il1fma [extracellular region]
(Danio rerio)
LOC105946938 [extracellular region]
(Xenopus tropicalis)
il1b [extracellular region]
(Xenopus tropicalis)
IL36RN [extracellular region]
(Bos taurus)
IL36RN [extracellular region]
(Canis familiaris)
IL36RN [extracellular region]
(Mus musculus)
Homologues of IL36RN [extracellular region]
(Xenopus tropicalis)
Il36rn [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_775262.1
,
NP_036407.1
OpenTargets
ENSG00000136695
ENSEMBL
ENSP00000259212
,
ENST00000346807
,
ENSP00000409262
,
ENST00000437409
,
ENST00000393200
,
ENSP00000376896
HPA
ENSG00000136695-IL36RN
PRO
Q9UBH0
Pharos - Targets
Q9UBH0
Orphanet
IL36RN
PDB
4P0L
,
4P0K
,
4P0J
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BWW4 SSBP3
0.718
8
UniProt:Q9BWG4 SSBP4
0.666
4
UniProt:Q9Y2T2 AP3M1
1
AP3M1 [cytosol]
(R-HSA-391288)
0.556
3
UniProt:Q969J2 ZKSCAN4
1
ZKSCAN4 [nucleoplasm]
(R-HSA-1027423)
0.556
3
UniProt:O95628-2 CNOT4
0.556
5
UniProt:Q9NWZ3 IRAK4
9
IRAK4 [cytosol]
(R-HSA-166081)
p-T342,T345,S346-IRAK4 [plasma membrane]
(R-HSA-936957)
IRAK4 [plasma membrane]
(R-HSA-937051)
p-T342,T345,S346-IRAK4 [endosome membrane]
(R-HSA-975149)
IRAK4 [endosome membrane]
(R-HSA-975167)
p-T342,T345,S346-IRAK4 [cytosol]
(R-HSA-446649)
IRAK4 E402* [cytosol]
(R-HSA-5602517)
IRAK4 R12C [cytosol]
(R-HSA-5602511)
IRAK4 Q293* [cytosol]
(R-HSA-5602426)
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:Q8N7F7 UBL4B
0.556
3
UniProt:P84074 HPCA
0.556
3
UniProt:O14492-2 O144922
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q8N4Y2-3 CRACR2B
0.556
3
UniProt:P81877 SSBP2
0.547
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:P10301 RRAS
1
RRAS [plasma membrane]
(R-HSA-396959)
0.527
2
UniProt:Q9NU19 TB22B
0.527
2
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