Reactome | cleaved GPI-LYPD3 [extracellular region]

cleaved GPI-LYPD3 [extracellular region]

Stable Identifier

R-HSA-8941013

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

GPI-LYPD3, Ly6/PLAUR domain-containing protein 3, LYPD3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95274 LYPD3

Gene Names

LYPD3, C4.4A, UNQ491/PRO1007

Chain

signal peptide:1-30, chain:31-326, propeptide:327-346

Reference Genes

BioGPS Gene:27076 LYPD3

COSMIC (genes):LYPD3 LYPD3

CTD Gene:27076 LYPD3

dbSNP Gene:27076 LYPD3

ENSEMBL:ENSG00000124466 LYPD3

HGNC:24880 LYPD3

Monarch:27076 LYPD3

NCBI Gene:27076 LYPD3

OMIM:609484 LYPD3

UCSC:O95274 LYPD3

Reference Transcript

RefSeq:NM_014400.2 LYPD3

Other Identifiers

11731579_a_at

16872982

204952_PM_at

204952_at

27076

3864376

3864377

3864378

3864379

3864380

3864381

3864382

3864383

3864384

3864385

3864386

3864387

41641_at

8037301

A_23_P39265

A_24_P48495

A_33_P3306264

GE54731

GO:0005576

GO:0005615

GO:0005886

GO:0007155

GO:0007160

GO:0016020

GO:0034392

GO:0043236

GO:0098552

HMNXSV003035985

ILMN_1739605

PH_hs_0018354

PH_hs_0035869

TC19001586.hg

g7656943_3p_at

Participates

as a member of

proteins with cleaved GPI-anchors [extracellular region] (Homo sapiens)

Other forms of this molecule

GPI-LYPD3 [plasma membrane]

Inferred To

LYPD3 [extracellular region] (Canis familiaris)

LYPD3 [extracellular region] (Sus scrofa)

Lypd3 [extracellular region] (Mus musculus)

Lypd3 [extracellular region] (Rattus norvegicus)

cleaved GPI-LYPD3 [extracellular region] (Bos taurus)

Modified Residues

Name

L-cysteine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 326

Coordinate

326

Modification

6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group

PsiMod Name

L-cysteine amide

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to L-cysteine amide.

Cross References

ENSEMBL

ENSP00000244333, ENST00000244333

OpenTargets

ENSG00000124466

HPA

ENSG00000124466-LYPD3

PRO

O95274

Pharos - Targets

O95274

GlyGen

O95274

PDB

6ION, 6IOM

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:O15228 GNPAT	3	GNPAT [cytosol] (R-HSA-9033129) GNPAT [peroxisomal membrane] (R-HSA-1500605) GNPAT [peroxisomal matrix] (R-HSA-53413)	0.527	2
UniProt:P24468 NR2F2	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
UniProt:Q969Z0 TBRG4	1	TBRG4 [mitochondrial matrix] (R-HSA-9837166)	0.527	3
UniProt:Q96AA3 RFT1	2	RFT1 R67C [endoplasmic reticulum membrane] (R-HSA-4570578) RFT1 [endoplasmic reticulum membrane] (R-HSA-449255)	0.527	2
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.527	2
UniProt:Q96IK1 BOD1	1	BOD1 [nucleoplasm] (R-HSA-9821926)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.527	2
UniProt:Q9H902 REEP1	1	REEP1 [endoplasmic reticulum membrane] (R-HSA-8939766)	0.527	2
UniProt:Q07065 CKAP4	7	CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956737) p-CKAP4 [endoplasmic reticulum lumen] (R-HSA-8956926) CKAP4 [azurophil granule membrane] (R-HSA-6799559) CKAP4 [plasma membrane] (R-HSA-5686306) CKAP4 [specific granule membrane] (R-HSA-6799552) PALM-C100-CKAP4 [plasma membrane] (R-HSA-5686280) PALM-C100-CKAP4 [lamellar body] (R-HSA-5686285)	0.527	3
UniProt:Q92538 GBF1	2	GBF1 [cytosol] (R-HSA-6807751) GBF1 [Golgi membrane] (R-HSA-199994)	0.527	2

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