Reactome | cleaved GPI-RECK [extracellular region]

cleaved GPI-RECK [extracellular region]

Stable Identifier

R-HSA-8941046

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

GPI-RECK, Reversion-inducing cysteine-rich protein with Kazal motifs, RECK_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95980 RECK

Gene Names

RECK, ST15

Chain

signal peptide:1-22, chain:23-942, propeptide:943-971

Reference Genes

BioGPS Gene:8434 RECK

COSMIC (genes):RECK RECK

CTD Gene:8434 RECK

dbSNP Gene:8434 RECK

ENSEMBL:ENSG00000122707 RECK

ENSEMBL_homo_sapiens_GENE:ENSG00000122707.12 RECK

HGNC:11345 RECK

KEGG Gene (Homo sapiens):8434 RECK

Monarch:8434 RECK

NCBI Gene:8434 RECK

OMIM:605227 RECK

UCSC:O95980 RECK

Reference Transcript

RefSeq:NM_021111.2 RECK

Other Identifiers

11725560_a_at

11755777_a_at

17084838

205407_PM_at

205407_at

3168311

3168312

3168313

3168320

3168322

3168324

3168327

3168330

3168334

3168336

3168337

3168347

3168348

3168349

3168350

3168351

3168353

3168354

3168355

3168357

3168360

3168362

3168364

3168366

3168367

3168369

3168370

3168371

3168372

3168373

3168374

3168375

35234_at

35236_g_at

8155169

8434

A_23_P83028

A_33_P3269899

GE57242

GO:0001955

GO:0002040

GO:0004866

GO:0004867

GO:0005515

GO:0005576

GO:0005886

GO:0007566

GO:0008191

GO:0015026

GO:0016020

GO:0016055

GO:0017147

GO:0022414

GO:0023052

GO:0030154

GO:0030198

GO:0030336

GO:0030414

GO:0035115

GO:0045765

GO:0048856

GO:0048870

GO:0060070

GO:0060089

GO:0090210

GO:0090263

GO:0098552

GO:0098772

GO:1904684

GO:1990909

HMNXSV003044863

ILMN_1688630

ILMN_2067269

PH_hs_0024485

TC09000201.hg

g11863155_3p_at

Participates

as a member of

proteins with cleaved GPI-anchors [extracellular region] (Homo sapiens)

Other forms of this molecule

GPI-RECK [plasma membrane]

Inferred To

GLIPR2 [extracellular region] (Canis familiaris)

RECK [extracellular region] (Bos taurus)

RECK [extracellular region] (Gallus gallus)

RECK [extracellular region] (Sus scrofa)

Reck [extracellular region] (Drosophila melanogaster)

Reck [extracellular region] (Mus musculus)

Reck [extracellular region] (Rattus norvegicus)

reck [extracellular region] (Danio rerio)

reck [extracellular region] (Xenopus tropicalis)

Modified Residues

Name

L-serine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 942

Coordinate

942

Modification

6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group

PsiMod Name

L-serine amide

PsiMod Definition

A protein modification that effectively converts an L-serine residue to L-serine amide.

Cross References

RefSeq

NP_066934.1

OpenTargets

ENSG00000122707

GeneCards

O95980

HPA

ENSG00000122707-RECK

Ensembl

ENSP00000367202, ENST00000377966, ENSG00000122707

PRO

O95980

Pharos - Targets

O95980

PDB

8TZP

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.556	4