Reactome: A Curated Pathway Database

Invadopodia formation

Stable Identifier
R-HSA-8941237
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to and degradation of the extracellular matrix (Linder & Kopp 2005, Murphy & Courtneidge 2011). They are characteristically composed of an actin-rich core surrounded by adhesion and scaffolding proteins. Current convention is to use the term podosome for the structures found in normal cells (such as monocytic cells, endothelial cells and smooth muscle cells) and in Src-transformed fibroblasts, and invadopodium for the structures found in cancer cells. The maturation process for podosomes and invadopodia involves the recruitment and activation of multiple pericellular proteases, which facilitates ECM degradation (Artym et al. 2006).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events