RUNX2 regulates genes involved in differentiation of myeloid cells

Stable Identifier
R-HSA-8941333
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
Both RUNX2 and RUNX1 can stimulate transcription of the LGALS3 gene, encoding Galectin-3 (Vladimirova et al. 2008, Zhang et al. 2009). Galectin 3 is expressed in myeloid progenitors and its levels increase during the maturation process (Le Marer 2000). Galectin 3 is highly expressed in pituitary tumors and glioma (Vladimirova et al. 2008, Zhang et al. 2009).
Literature References
PubMed ID Title Journal Year
18438928 Runx2 is expressed in human glioma cells and mediates the expression of galectin-3

Pesheva, P, Vladimirova, V, Lückerath, K, Probstmeier, R, Waha, A

J. Neurosci. Res. 2008
10816326 GALECTIN-3 expression in differentiating human myeloid cells

Le Marer, N

Cell Biol. Int. 2000
19020999 RUNX1 and RUNX2 upregulate Galectin-3 expression in human pituitary tumors

Coonse, K, Zhang, HY, Jin, L, Tanizaki, Y, Lloyd, RV, Raz, A, Ruebel, KH, Stilling, GA

Endocrine 2009
Participants
Participates
Cross References
BioModels Database
Authored
Reviewed
Created
Cite Us!