Superoxide and nitric oxide react to peroxynitrite in the phagosome

Stable Identifier
R-HSA-8942052
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inside the phagosome, nitric oxide and superoxide react at diffusion controlled rates with each other to yield peroxynitrite (Prolo C et al. 2014; Ferrer-Sueta G & Radi R 2009).

Literature References
PubMed ID Title Journal Year
7762673 The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

Pryor, WA, Squadrito, GL

Am J Physiol 1995
24281946 Peroxynitrite, a potent macrophage-derived oxidizing cytotoxin to combat invading pathogens

Prolo, C, Alvarez, MN, Radi, R

Biofactors 2014
8396550 The reaction of no with superoxide

Huie, RE, Padmaja, S

Free Radic. Res. Commun. 1993
20194496 Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: direct reaction with boronate-based fluorescent probe

Zielonka, J, Sikora, A, Joseph, J, Kalyanaraman, B

J. Biol. Chem. 2010
Participants
Participant Of
Cross References
Rhea
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Created