RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B

Stable Identifier
R-HSA-8942099
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The ubiquitin E3 ligase complex RNF20:RNF40 (also known as Bre1 in Saccharomyces cerevisiae) interacts with the PAF complex and the E2-ubiquitin conjugate UBE2A,B:Ubiquitin (RAD6:Ubiquitin in Saccharomyces cerevisiae) (Zhu et al. 2005, Kim et al. 2009, Hahn et al. 2012, Foglizzo et al. 2016). The complex binds nucleosomal histone H2B after which RNF20:RNF40 monoubiquitinates histone H2B (Zhu et al. 2005, Kim et al. 2009). RNF20:RNF40 also binds WAC, which targets RNF20:RNF40 to the RNA polymerase II complex and promotes monoubiquitination of histone H2B (Zhang and Yu 2011).

Literature References
PubMed ID Title Journal Year
16307923 Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

Zhu, B, Zheng, Y, Pham, AD, Mandal, SS, Erdjument-Bromage, H, Tempst, P, Reinberg, D

Mol. Cell 2005
19410543 RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

Kim, J, Guermah, M, McGinty, RK, Lee, JS, Tang, Z, Milne, TA, Shilatifard, A, Muir, TW, Roeder, RG

Cell 2009
22021426 The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination

Hahn, MA, Dickson, KA, Jackson, S, Clarkson, A, Gill, AJ, Marsh, DJ

Hum. Mol. Genet. 2012
21329877 WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription

Zhang, F, Yu, X

Mol. Cell 2011
27569044 Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B

Foglizzo, M, Middleton, AJ, Day, CL

J. Mol. Biol. 2016
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