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WAC [nucleoplasm]
Stable Identifier
R-HSA-8942150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
WW domain-containing adapter protein with coiled-coil, WAC_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
WAC [nucleoplasm] (Homo sapiens)
WAC [nucleoplasm] (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
WAC [nucleoplasm] (Homo sapiens)
WAC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BTA9 WAC
Gene Names
WAC, KIAA1844
Chain
chain:1-647
Reference Genes
COSMIC (genes):WAC WAC
dbSNP Gene:51322 WAC
ENSEMBL:ENSG00000095787 WAC
Participates
as an output of
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
as a component of
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
as an input of
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
Inferred To
wac-1.1 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of WAC [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of WAC [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of WAC [nucleoplasm]
(Schizosaccharomyces pombe)
Wac [nucleoplasm]
(Mus musculus)
Wac [nucleoplasm]
(Rattus norvegicus)
waca [nucleoplasm]
(Danio rerio)
wac [nucleoplasm]
(Xenopus tropicalis)
wcy [nucleoplasm]
(Drosophila melanogaster)
WAC [nucleoplasm]
(Bos taurus)
WAC [nucleoplasm]
(Canis familiaris)
WAC [nucleoplasm]
(Gallus gallus)
WAC [nucleoplasm]
(Sus scrofa)
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19012 KRT15
1
KRT15 [cytosol]
(R-HSA-6809589)
0.666
4
IntAct:EBI-10171556 147700
0.556
3
UniProt:Q8TDW5 SYTL5
0.556
3
UniProt:Q8WWB3 DYDC1
0.556
3
UniProt:Q6P597 KLC3
1
KLC3 [cytosol]
(R-HSA-983232)
0.556
3
UniProt:Q9Y228 T3JAM
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:Q99996-2 AKAP9
0.556
3
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.556
3
UniProt:O75150 RNF40
1
RNF40 [nucleoplasm]
(R-HSA-5689015)
0.527
3
UniProt:Q5VTR2 RNF20
2
RNF20 [cytosol]
(R-HSA-9715141)
RNF20 [nucleoplasm]
(R-HSA-5689011)
0.527
2
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